ODCs

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2 OMIM references -
2 associated genes
18 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

1 OMIM reference -
1 associated gene
8 signs/symptoms

Porphyria cutanea tarda

Congenital atransferrinemia

HFE	(UniProt - OMIM)		TF	(UniProt - OMIM)
UROD	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	HFE	(0.52)	TF

Citations in the biomedical literature:

Porphyria cutanea tarda		Congenital atransferrinemia
	Synonym(s): - PCT		Synonym(s): - Congenital hypotransferrinemia

	Classification (Orphanet): - Inborn errors of metabolism - Rare eye disease - Rare genetic disease - Rare renal disease - Rare skin disease		Classification (Orphanet): - Inborn errors of metabolism - Rare genetic disease - Rare hematologic disease

	Classification (ICD10): - Endocrine, nutritional and metabolic diseases -		Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: adulthood Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal recessive

	External references: 2 OMIM references - 1 MeSH reference: D017119		External references: 1 OMIM reference - 1 MeSH reference: C538259

Porphyria cutanea tarda		Congenital atransferrinemia
	Very frequent - Autosomal dominant inheritance - Cutaneous rash - Erythema / erythematous lesions / erythroderma / polymorphous erythema - Irregular / in bands / reticular skin hyperpigmentation - Irregular / patchy skin hypopigmentation - Skin photosensitivity - Thin skin - Vesicles / bullous / exsudative lesions / bullous / cutaneous / mucosal detachment Occasional - Abnormal scarring / cheloids / hypertrophic scars - Acute palsy - Cirrhosis - Collapse / sudden death / cardiac arrest / cardiorespiratory arrest - Cutaneous edema - Hepatic / liver neoplasm / tumor / carcinoma / cancer - Hirsutism / hypertrichosis / Increased body hair - Liver / hepatic steatosis - Obnubilation / coma / lethargia / desorientation		Very frequent - Anaemia - Autosomal recessive inheritance Frequent - Immunodeficiency / increased susceptibility to infections / recurrent infections Occasional - Arthritis / synovitis / synovial proliferation - Hypothyroidy - Structural anomalies of the cardio-circulatory system - Structural anomalies of the pancreas